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ONGOING PROJECTS

Please click on the respective TBnet # to see details of the respective projects. You have to be a registered member and have to log in to the webpage to see the respective details.

 


TBnet #16 A database for paediatric tuberculosis in Europe

Principal investigator: Beate Kampmann (UK)

This study was facilitated by the award of the TBnet Grant 2010. The project started in October 2010. The data-base will include (1) demographic characteristics (2) information about active TB and Microbiology (3) LTB (4)Follow-up (5) children with TB contact but not treated and (6) adverse events of treatment.


TBnet #34 / NTM-NET #5 Treatment of M. xenopi infections (CaMoMy Trial) 

Principal Investigator: Claire Andrejak

The main objective of this study is to determine the 6-months sputum conversion rate with a clarithromycin- or moxifloxacin-containing regimen in patients with a M. xenopi pulmonary infection. This study is originally located and facilitated in France, other European centers are now asked to participate.


TBnet #39 Differentiation of antigen-specific T-cells in pulmonary tuberculosis 

Principal Investigator: Barbara Kalsdorf (Germany)

This study aims to characterize the immunophenotype and function of peripheral blood and BAL-derived Mycobacterium (M.) tuberculosis specific T-cells in suspects of tuberculosis to identify whether expansion of antigen-specific T-cells occurs only at a central compartment (lymph nodes) or in addition, at the site of the infection. We will identify the phenotype of unstimulated and antigen-specific T-cells in blood and BAL for the ability to relocate (CD3, CD4, CD8, CD27, CD45RO, CCR7) and to replicate at the site of infection (CD25, IL-2, Ki67). Early apoptosis markers like Annexin V will be used on blood and BAL-cells to investigate whether the local activation of M. tuberculosis-specific CD4 /CD8 T-cells induces protection against cell death in the course of acute pulmonary infection.


TBnet #47 Metabolomic profile in TB

Principal investigator: Jose Dominguez (E) Pilot Study completed.

The aim of this study is to characterize the specific urinary metabolome released from TB patients by nuclear magnetic resonance in order to be used for diagnostic purposes. The study also aims to evaluate the utility of serial NMR metabolomic determinations in monitoring the efficacy of the treatment

Document A: Study Protocol

Document B: Study Desciption

Document C: Ethical Approval (Spain)


 

TBnet #52 Management of tuberculosis in transplant recipients,

Principal Investigator: Martina Sester (Germany), Berit Lange (Germany)

Influence of screening for tuberculosis on tuberculosis incidence after organ transplantation in regions of tuberculosis incidence of <40/100000

INSTRUCTION (version 02.12.2015)    STUDY PROTOCOL (version 02.12.2015)   TBnet FORM (version 13.04.2016)


TBnet #53 TBnet-DM Study. Socio-demographic and clinical characteristics of patients with Tuberculosis and Diabetes in Europe

 Principal Investigator: Enrico Girardi (Italy)

This study aims to describe the epidemiology, and clinical presentation of  tuberculosis in patients with diabetes in Europe. Specific objectives are: 1.To determine the prevalence of DM among TB patients  in Europe with special reference to possible differences among different countries and between autochthonous and migrant patients. 2. To analyze epidemiological and demographic variables associated with DM among TB patients. 3. To describe clinical presentation  of TB-DM and diagnosis of DM in TB patients 

Protocol and Appendix can be found here (only for members).


TBnet #54 Performance of a new generation IGRA in immunocompromised individuals

Principal Investigator: Martina Sester (Germany)

The availability of a test for the sensitive detection of LTBI is particularly important in immunocompromised patients. Due to systemic immunosuppression, immunocompromised patients with latent M. tuberculosis infection are at increased risk of progression to active disease after exposure. This applies to patients with various causes of immunodeficiency such as HIV-infected patients, allogeneic stem cell and solid organ transplant recipients, patients with rheumatoid arthritis and patients with chronic renal failure (2-5). Therefore, current guidelines aimed at preventing tuberculosis infection in immunocompromized individuals recommend a screening for evidence of latent infection to target appropriate preventative prophylaxis (1, 6-13). Read more on the proposal.

Document A: Study Entry Form

Document B: Study Protocol

Document C: Ethical Approval (Germany)


 

TBnet # 55 Clinical Evaluation of miniMDR-TB® test kit

Principal investigator: Sven Hoffner (SE)


TBnet # 56  P.A.T. Study

 

Personalization of AntiTB Treatment:

evaluation of pharmacological determinants of treatment response, Principal Investigator: Ilaria Motta


For discussion: an ongoing data collection and biobank for TBnet members

In Barcelona, at the 8th TBnet Annual Meeting, a common database and biobank was suggested.  Details for this are available under the "members only section".
 
Membership of TBnet is free - please follow the link to apply.